Cefoperazone/Sulbactam should be reconstituted with the appropriate amount of 5% Dextrose in Water, 0.9% Sodium Chloride Injection or Sterile Water for Injection and then diluted to 20 ml with the same solution.
Till reconstitution, store below 25°C and protect from light.
Reconstituted solutions are stable for 7 days at 2°C-8°C and for 24 hours at 8°C-25°C.
The usual adult dose of Sulbactam /Cefoperazone is 2 to 4 g per day (i.e. 1 to 2 g per day cefoperazone activity) given intravenously or intramuscularly in equally divided doses every 12 hours.
In severe or refractory infections the daily dosage of sulbactam/cefoperazone may be increased up to 8 g (i.e., 4 g cefoperazone activity) given intravenously in equally divided doses or 12 g of the 1:2 ratio. The recommended maximum daily dosage of sulbactam is 4 g (i.e., 8 g of sulbactam/cefoperazone).
The usual dosage of sulbactam/cefoperazone in children is 40 to 80 mg/kg/day (i.e. 20-40 mg/kg/day cefoperazone) in 2 to 4 equally divided doses.
In serious or refractory infections, these dosages may be increased up to 160 mg/kg/day (80 mg/kg/day of cefoperazone) of the 1:1 ratio or 240 mg/kg/day (160 mg/kg/day cefoperazone activity) of the 1:2 ratio. Doses should be administered in 2 to 4 equally divided doses (see section 4.4 Special Warnings and Precautions for Use, Use in Infancy and section 6.1 Animal Toxicology or Pharmacology).