Adults :
For most gram-positive infections:

Loading regimen of three 12-hourly doses of 400 mg IV, followed by a maintenance dose of 400 mg IV or IM once daily. The standard dose of 400 mg equates to approximately 6 mg/kg. In patients weighing more than 85 kg, a dose of 6 mg/kg should be used.

Surgical Prophylaxis:400 mg (or 6 mg/kg if >85 kg) IV single dose at time of anesthesia induction.

Pediatrics :

>2 months to 16 years: For most gram-positive infections: loading regimen of three 12-hourly doses of 10 mg/kg IV, followed by a maintenance dose of 6 mg/kg IV or IM once daily. Severe infections and infections in the neutropenic patient: Loading regimen of three 12-hourly doses of 10 mg/kg IV, followed by 10 mg/kg IV once daily.

Route of Administration:

IV/IM

Reconstitution :

• Dilute 400mg doses in 3ml of water for Injection.
• The intravenous injection may be administered either as a bolus over 3 to 5 minutes or as a 30-minute infusion.

Storage :

• Store at room temperature.
• The vials should be protected from heat.
• Reconstituted solutions should be stored under refrigeration (5°C) and solutions stored for longer than 24 hours be discarded.