Flucloxacillin Sodium Powder for Injection is the sodium salt of flucloxacillin. Flucloxacillin is 3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolylpenicillin monohydrate. It is a member of the beta-lactamase-stable group of penicillins derived from the penicillin nucleus, 6-amino penicillanic acid. Flucloxacillin is closely related to cloxacillin.
The chemical formula of flucloxacillin sodium is C19H16CIFN3NaO5S,H2O. Its molecular weight is 493.9 Flucloxacillin sodium is a white or almost white, crystalline powder, hygroscopic, freely soluble in water and in methanol, soluble in alcohol.Flucloxacillin Sodium Powder for Injection contains 1 g of flucloxacillin as flucloxacillin sodium

Usual adult dosage : Intramuscular 250 mg 6 hourly.Intravenous 250 mg to 1 g 6 hourly ,Intrapleural 250 mg once daily, Intra-articular 250 mg to 500 mg once daily Note: Systemic doses may be doubled where necessary in severe infections.
Usual children's dosage: 2 to 10 years 1/2 adult dose, under 2 years 1/4 adult dose Note: In severe infections the dosage may be increased.
Dosage in patients with impaired liver function: Adjustment of dosage may not be necessary as flucloxacillin is not metabolised in the liver to any appreciable extent. However, during prolonged treatment it is advisable to check periodically for hepatic dysfunction. Dosage in patients with impaired renal function As flucloxacillin is excreted to a large extent by the kidney, the dose or dose interval may need modification in patients with renal failure, as the half life in patients with renal failure is increased. However dosage recommendations for various plasma creatinine levels for patients with impaired renal function are not available. Flucloxacillin is not significantly removed by haemodialysis.
STORAGE : Flucloxacillin Sodium Powder for Injection should be stored in a dry place at less than 250C. Protect from light and moisture.