Adult dose	Pediatric Treatment
Bacteremia	IM: 25,000 to 30,000 units/kg/day IM divided every 4 or 6 hours IV: 15,000 to 25,000 units/kg/day IV divided every 12 hours	IM: 25,000 to 40,000 units/kg/day IM divided every 4 or 6 hours IV: 15,000 to 40,000 units/kg/day IV divided Q12H
Urinary Tract Infection	IM: 25,000 to 30,000 units/kg/day IM divided every 4 or 6 hours IV: 15,000 to 25,000 units/kg/day IV divided every 12 hours	IM: 25,000 to 40,000 units/kg/day IM divided every 4 or 6 hours IV: 15,000 to 40,000 units/kg/day IV divided every 12 hours
Ocular Infection	Subconjunctival injection: Inject up to 100,000 units/day subconjunctivally
Meningitis	Initial dose: 50,000 units intrathecally once a day for 3 to 4 days Maintenance dose: 50,000 units intrathecally every other day	Initial dose: 20,000-50,000 units intrathecally once a day for 3 to 4 days Maintenance dose: 25,000-50,000 units intrathecally every other day

Route of Administration:

IV/IM

Reconstitition :

• Reconstitute polymyxin B (500,000 units) in 20 to 50 mL of Sterile Water for Injection or 0.9% Sodium Chloride Injection to yield 1 to 2.5 mg/mL (10,000 to 25,000 units/mL or 0.1% to 0.25%).

Storage :

• Before reconstitution:
  Store at room temperature (15-30°C). Protect from light. Retain in carton until time of use.
• After reconstitution: For Intravenous, Intramuscular, Intrathecal and Ophthalmic (Subconjunctival): Reconstituted solutions should be stored under refrigeration (2-8°C) and the unused portion should be discarded after 24 hours.

Category :

• Polymyxin B: is a polymyxin antibiotic used to treat a wide variety of infections in the body.